How much motion is too much motion? Determining motion thresholds by sample size for reproducibility in developmental resting-state MRI

How much motion is too much motion? Determining motion thresholds by sample size for reproducibility in developmental resting-state MRI

Blog Article

A constant problem developmental neuroimagers face is in-scanner head motion.Children move more than adults and this has led to concerns blueberry bubblicious that developmental changes in resting-state connectivity measures may be artefactual.Furthermore, children are challenging to recruit into studies and therefore researchers have tended to take a permissive stance when setting exclusion criteria on head motion.The literature is not clear regarding our central question: How much motion is too much? Here, we systematically examine the effects of multiple motion exclusion criteria at different sample sizes and age ranges in a large openly available developmental cohort (ABIDE; http://preprocessed-connectomes-project.

org/abide).We checked 1) the reliability of resting-state functional magnetic resonance imaging (rs-fMRI) pairwise connectivity measures across the brain and 2) the accuracy with which we can separate participants with ferm living hoop autism spectrum disorder from typically developing controls based on their rs-fMRI scans using machine learning.We find that reliability on average is primarily sensitive to the number of participants considered, but that increasingly permissive motion thresholds lower case-control prediction accuracy for all sample sizes.